Hyalase™ is an enzyme which breaks down hyaluronic acid. Hyaluronic acid is the component of dermal fillers, but is also naturally occurring in the skin and soft tissues.  Hyalase™ (hyaluronidase 1500 units) is licensed and commonly used to boost absorption or dispersal of drugs injected into the skin and has an off license use in aesthetic medicine.

Occasionally dermal fillers need to be dissolved when the treatment outcome is unacceptable, when an adverse reaction to the implant has occurred, or there is a possibility of vascular occlusion and/or impending necrosis (tissue death) which could lead to the compromise of healthy tissue.

Massaging the area or leaving the dermal filler to break down naturally which may take several months dependent on the type of filler used and the area treated.


  • Pain or stinging sensation during the treatment
  • Localised swelling, which can be marked in the first 24 – 72 hours post treatment
  • Redness and/or tenderness
  • Bruising, rarely bruising may be severe and may persist for several weeks
  • Numbness or itching in the treated area following injection
  • Loss of volume of the natural tissue beyond correction of the filler
  • Skin laxity which is expected to be temporary, but may be disfiguring until your own Hyalauronic Acid is replenished



  • Infection
  • Inflammation
  • Allergic Reaction and Severe Allergic Reaction including Anaphylaxis, if treatment is indicted for cosmetic correction you will be given a small injection into the forearm 30 minutes before to test patch before a treatment is administered.


A small percentage of the population may be severely allergic to Hyaluronidase, particularly those who are allergic to bee stings. Hyalase™ administration can result in anaphylaxis a severe allergic reaction which in itself is life threatening and requires immediate medical attention and hospitalisation.



Hyalase can be used for emergency dissolving of fillers which is required when there is a vascular occlusion, (the filler has blocked a blood vessel) the Hylase is reconstituted differently in this situation.  When the Hylase is required for cosmetic reasons to dissolve or soften the area it will still be unpredictable and therefore no guarantee can be made that the cosmetic outcome will be satisfactory.  You must understand that you may require further Hylase treatment sessions at at least 1 week interval or re-treatment of filler at may be necessary to achieve the desired result.

Common side effects are expected to resolve spontaneously, within the first few days of treatment. Whilst not expected, it is possible that reactions described may persist for longer than expected and may inhibit your confidence to attend work or social events. You are advised to schedule treatment with this in mind, allowing time for common reactions such as bruising and swelling to settle.


  • You will be advised to stay in clinic for 30 minutes to ensure that you are not experiencing an allergic reaction.
  • You can expect bruising and/or swelling.
  • You may be required to gently massage the treated area, your Practitioner will advise and instruct
  • You must report any other effects immediately
  • You can have dermal filler treatment after all the swelling and bruising has resolved only if your Practitioner agrees, in the event of emergency Hylase treatment you will need to wait up to three months before re-treatment.



I understand that though complications are uncommon, they do sometimes occur. It is possible that side effects not described may occur and indeed that a complication not previously reported may occur for the first time. I understand if I suffer any adverse reactions that are not expected, or concern me, I must contact my practitioner, and book a review appointment.  MD Medical Aesthetics Ltd cannot take responsibility for complications or results that have not been reported, assessed, documented and managed in a timely manner.  Whilst I have been advised of the probable result, this cannot be interpreted as a guarantee. Results vary from one individual to another.

I confirm that the medical health history form has been completed truthfully and I am fully aware that withholding medical information, including history of previous treatment, may be detrimental to the safe and optimal outcome of any treatment administered.  If there are any changes in my medical history, I must inform the practitioner.

I confirm that I have been provided with verbal and written information about this treatment which includes aftercare and follow up advice and I agree to follow the aftercare advice and understand this reduces risk of adverse reactions and helps ensure optimum results.

I understand information about me will be treated as confidential and access to it restricted in accordance with the Data Protection Act, unless specific permissions given.

By consenting to treatment you accept the clinic terms and conditions as outlined:

  • You are satisfied that the treatment has been explained comprehensively
  • That the possible risks and side effects associated with the treatment have been fully discussed and understood
  • That you have taken sufficient time to process and consider the information provided and any questions have been answered to your satisfaction, before making a decision to proceed with the agreed treatment plan.
  • You consent to your medical records being shared with appropriate professional staff
  • You accept emergency intervention treatment if required